Culture PCR Species Risk Factors Site Empiric Therapy Targeted Therapy Surgery IFD Final Response Patient alive Year of Infection
Rhizopus arrhizus Diabetes mellitus Bones, Paranasal sinus(es) Posaconazole Bone resection maxilla Complete Response Yes 2009
Culture available Rhizopus arrhizus Immunosuppression, Cancer Other (Multiple Myeloma), Hematopoietic stem cell transplantation (HSCT) Deep soft tissues, Lungs, Paranasal sinus(es), Skin Voriconazole Posaconazole , Other Radical resection of right lower jaw, orbitotomy, nasal ablation Deterioration or failure No 2008
Rhizopus arrhizus Cancer Other (Aplastic Anemia) Eyes, Gastrointestinal tract, Lungs, Paranasal sinus(es) Amphotericin B lipid complex Amphotericin B lipid complex, Posaconazole , Itraconazole Resection of the terminal ileum and cecum Complete Response Yes 2010
Rhizopus arrhizus Corticosteroids, Immunosuppression, Cancer (AML), Chemotherapy, Chronic pulmonary disease, Hematopoietic stem cell transplantation (HSCT), ICU, Neutropenia Deep soft tissues, Gastrointestinal tract, Liver, Lungs, Peritoneum, Spleen Deterioration or failure No 2010
Culture available Rhizopus arrhizus Diabetes mellitus, ICU, Trauma Deep soft tissues, Skin Amphotericin B deoxycholate Wound debridement Deterioration or failure No 2006
Culture available Rhizopus arrhizus Diabetes mellitus, ICU CNS, Eyes Caspofungin, Fluconazole Liposomal amphotericin B Debridement Deterioration or failure No 2010
Rhizopus arrhizus Chronic renal disease, Corticosteroids CNS, Paranasal sinus(es) Liposomal amphotericin B, Posaconazole solution Cerebral abscess surgery and surgery of the paranasal sinus(es) Complete Response Yes 2011
Rhizopus arrhizus Immunosuppression, Cancer (CLL), Hematopoietic stem cell transplantation (HSCT) Lungs Liposomal amphotericin B, Terbinafine, Voriconazole Deterioration or failure No 2011
Rhizopus arrhizus Corticosteroids, Cancer (ALL), Chemotherapy, Neutropenia Deep soft tissues Amphotericin B lipid complex, Micafungin Amphotericin B lipid complex, Micafungin Debridement Complete Response Yes 2011
Rhizopus arrhizus Corticosteroids, Immunosuppression, Cancer (AML), Diabetes mellitus, Hematopoietic stem cell transplantation (HSCT) Bones, Eyes, Paranasal sinus(es) Fluconazole Caspofungin, Liposomal amphotericin B, Posaconazole Decompression of left orbita and debridement of leftsided sinusitis Deterioration or failure No 2010
Culture available Rhizopus arrhizus ICU, Major surgery Lungs Liposomal amphotericin B Deterioration or failure No 2012
Rhizopus arrhizus Corticosteroids, Immunosuppression, Cancer (AML), Hematopoietic stem cell transplantation (HSCT), ICU Paranasal sinus(es) Liposomal amphotericin B Unknown Yes 2012
Rhizopus arrhizus Immunosuppression, Cancer (ALL), Chemotherapy, Hematopoietic stem cell transplantation (HSCT), Neutropenia Lungs, Paranasal sinus(es) Micafungin, Amphotericin B lipid complex Amphotericin B lipid complex Functional endoscopic sinus surgery (FESS) - failed Deterioration or failure No 2012
Rhizopus arrhizus Corticosteroids, Diabetes mellitus, ICU, Solid organ transplantation Eyes, Paranasal sinus(es), Skin Liposomal amphotericin B Stable Disease No 2013
Rhizopus arrhizus Corticosteroids, ICU, Rheumatic disease/Autoimmune disease (ANA-positive mouth ulcers) CNS, Eyes, Paranasal sinus(es) Amphotericin B deoxycholate Deterioration or failure No 2013
Rhizopus arrhizus Chronic renal disease, Diabetes mellitus Paranasal sinus(es) Liposomal amphotericin B Functional endoscopic sinus surgery (FESS) Complete Response Yes 2015
Culture available Rhizopus arrhizus Cancer (Lymphoma), Neutropenia Lungs, Other: Pleuritis Amphotericin B liposomal, Posaconazole Pleural drainage and local resection Partial Response No 2008
Rhizopus arrhizus Cancer (AML), Chemotherapy, Neutropenia, Other: Colitis ulcerosa Bones, Skin and Deep soft tissues Caspofungin Amphotericin B liposomal, Posaconazole Craneotomy with bone and soft tissue resection Complete Response No 2014
Rhizopus arrhizus Neutropenia, ICU, Other: Near-drowning in a goose pond Lungs Amphotericin B liposomal Complete Response Yes 2014
Rhizopus arrhizus Corticosteroids, Immunosupression, Cancer (Lymphoma), Chemotherapy, Neutropenia Lungs Voriconazole Amphotericin B lipid complex, Caspofungin, Posaconazole Partial Response Yes 2015
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Principle Investigator:
Prof. Oliver A. Cornely, MD, FACP, FIDSA, FAAM, FECMM, Cologne, Germany
Project Manager:
Danila Seidel, PhD, Cologne, Germany
Coordinating physician:
Maria J. G. T. Vehreschild, MD, Cologne, Germany
Epidemiology & Statistics:
J. Janne Vehreschild, MD, FECMM, Cologne, Germany