Culture PCR Species Risk Factors Site Empiric Therapy Targeted Therapy Surgery IFD Final Response Patient alive Year of Infection
Apophysomyces elegans Trauma Skin and Deep soft tissues Amphotericin B liposomal 3 surgeries Complete Response Yes 1997
Apophysomyces variabilis Diabetes mellitus, Trauma Skin and Deep soft tissues Amphotericin B liposomal 8 surgeries Progression No 2012
Apophysomyces variabilis Trauma Skin and Deep soft tissues Amphotericin B deoxycholate, Posaconazole Surgical washings. Also on , -2, 0, 2, 5, 7, 10, 14 and 17 Complete Response Yes 2016
Conidiobolus coronatus No risk factor identified Skin Itraconazole Partial Response Yes 2014
Culture available Conidiobolus spp. No risk factor identified Deep soft tissues Unknown Yes 2008
Culture available Cunninghamella bertholletiae Corticosteroids, Immunosupression, Cancer Other (Myelodysplastic Syndrom), Chemotherapy, Neutropenia, Rheumatic disease/Autoimmune disease Skin and Deep soft tissues Amphotericin B liposomal, Posaconazole Progression No 2018
Cunninghamella bertholletiae Cancer (Chronic Leukemia), Chemotherapy Thyroid Amphotericin B liposomal, Posaconazole Drainage of neck mass Complete Response Yes 2018
Cunninghamella blakesleeana Cancer (ALL), Hematopoietic stem cell transplantation (HSCT) - Allogeneic, Chemotherapy, Neutropenia, Other: Radiotherapy Lungs Amphotericin B liposomal Progression No 2010
Cunninghamella spp. Cancer Other (Prolymphocytic Leukemia), Chemotherapy, Neutropenia Lungs Voriconazole Liposomal amphotericin B Deterioration or failure No 2010
Cunninghamella spp. Cancer Other (Aplastic Anemia), Hematopoietic stem cell transplantation (HSCT) - Allogeneic, Chemotherapy CNS Amphotericin B liposomal Cerebral abscess drainage Stable Disease No 2015
Cunninghamella spp. Corticosteroids, Immunosupression, Cancer Other (Multiple Myeloma), Chemotherapy, Chronic renal disease Skin and Deep soft tissues Amphotericin B deoxycholate, Amphotericin B liposomal 2 surgical debridements Complete Response Yes 2000
Lichtheimia corymbifera Cancer (AML), Chemotherapy, Neutropenia Deep soft tissues, Skin Posaconazole, Amphotericin B lipid complex Surgical debridement of necrotic tissue from ulcers (right leg) - repeatedly Partial Response No 2008
Culture available Lichtheimia corymbifera Immunosuppression, Cancer (CML), Hematopoietic stem cell transplantation (HSCT) Lungs Liposomal amphotericin B, Caspofungin Partial Response Yes 2009
Culture available Lichtheimia corymbifera Immunosuppression, Cancer Other (Multiple Myeloma), Hematopoietic stem cell transplantation (HSCT), ICU Lungs Liposomal amphotericin B, Posaconazole Deterioration or failure No 2008
Lichtheimia corymbifera ICU, Trauma, Corticosteroids Gastrointestinal tract Fluconazole Liposomal amphotericin B, Voriconazole, Posaconazole solution Ileocolectomy Complete Response Yes 2007
Lichtheimia corymbifera Corticosteroids, Alcoholism, Solid organ transplantation Biliary system Liposomal amphotericin B Resection Complete Response Yes 2008
Culture available Lichtheimia corymbifera Diabetes mellitus, Solid organ transplantation Bones, Paranasal sinus(es) Liposomal amphotericin B Functional endoscopic sinus surgery (FESS) Complete Response Yes 2007
Lichtheimia corymbifera Trauma Deep soft tissues, Skin Liposomal amphotericin B, Posaconazole Complete Response Yes 2007
Lichtheimia corymbifera Cancer (ALL), Chemotherapy Lungs Liposomal amphotericin B Liposomal amphotericin B, Voriconazole, Posaconazole , Caspofungin Lobectomy (middle, right) Complete Response Yes 2007
Culture available Lichtheimia corymbifera Solid organ transplantation Lungs Posaconazole Thoracotomy and resection of lesions, decortication Complete Response Yes 2007
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Principle Investigator:
Prof. Oliver A. Cornely, MD, FACP, FIDSA, FAAM, FECMM, Cologne, Germany
Project Manager:
Danila Seidel, PhD, Cologne, Germany
Coordinating physician:
Maria J. G. T. Vehreschild, MD, Cologne, Germany
Epidemiology & Statistics:
J. Janne Vehreschild, MD, FECMM, Cologne, Germany